Discussions up to 24th June 2017

Dr
27yrs male patient suffering from lipomas since 10yrs
Plz suggest treatment
Already two times surgery done

Plz suggest treatment

Payal K:
Arogyavardhini, kanchanar guggulu / triphala guggulu, rasapachak , raktapachak & medo pachak

Surekha Mitta Dr.:
Hello friends ! A 67 year old male detected as 2nd stage stomach cancer. Not fit for surgery or radiation due to lowered health status. His bystanders want to try Ayurvedic treatment. He stays in Bihar near Patna. Would any of our friends who stay in Patna like to take up the case? Please let me know

Dr.kamal:
Patient weight??? Age???

Dr Kaveti Rajyalakshmi:
IDr Kaveti Rajyalakshmi:
These are lipomas. Requires weekly virechana with aswakanchuki ras. Medohara treatment will benefit. Takes not less than two years to reduce. Diet correction is must and should. I treated two cases.

Dr.nageswr Gokul:
Dr.Nageswara Rao.V:
Bhasma as a medicine and the toxicity aspect

 Minerals are essential for the proper function and structure of a cell. However, the human body cannot absorb most of the minerals in their natural (inorganic) form. The body has to recognize them as food. This food is provided by plants that process inorganic minerals from the soil into organic minerals that can be well absorbed by the human body. Concern has been expressed about the poisonous nature of the deified red sulfide of mercury (cinnabar/makardhwaja) and the red oxide of lead. There is a detailed description of their medicinal virtues in the texts22. Lead and mercury exposures of the human body and their harmful effects have been studied26. The absorption of inorganic compounds of mercury in the human body is poor to moderate when administered orally. Its half-life of stay in the blood is 40-60 days. The absorption of organic compounds of mercury is complete and the half-life in this case is about 70 days. Once absorbed, it is mainly distributed into the central nervous system and the kidneys. Its elimination is through excreta. Lead in both its inorganic and organic form is absorbed through the gastrointestinal tract. Once absorbed, it lands up in soft tissues (brain, liver, kidneys). Its half-life of stay in the blood is about 30 days. It is excreted through the kidneys. Chelation therapies have been used to bring down the levels of the toxic metals in patients. However, these require a careful monitoring. It has been expressed that probably the metals while being made into a bhasma get chelated with organic molecules (ligands) obtained from the herbs for these to be better assimilated27. To improve absorptivity and be less reactive in the digestive tract, a metal ion is bonded or chelated to an organic molecule, an amino acid or a hydrolyzed protein (a kind of a Trojan Horse). However, a bhasma when prepared is not a chelate; it tests to be an inorganic compound only. The bhasmas do show up with traces of certain other elements present in them. These come from the impurities, specific treatments and the crucibles and the vessels used15,18. Any organometallic complex compound has to survive the several incinerations at very high temperatures and if at all can be present in extremely small proportions only. Incidentally, minerals taken with a meal get usually automatically chelated in the stomach during digestion28.

 

 Thus, one has to contend with the simple inorganic compound form of the metal only that’s medicinal value and the attributed pharmacological action is to be scientifically ascertained and its absorption and stay in the body is to be quantitatively determined till it is drained out. Many metal oxides are toxic; in comparison, a sulfide of a metal is generally less toxic compared to its oxide or chloride, being relatively less soluble in the body fluids. As bhasmas are mostly oxides only, the toxicities need to be evaluated. Probably, to check the toxic accumulations, a bhasma is traditionally administered with an anupaana (vehicle) such as honey, milk or butter, etc. This has been empirically known but the knowledge is mostly qualitative. Some of the observations as follows provide more definite indications to the safety factor behind the use of bhasmas compared to the plain salts of the same metals that are toxic in high doses. Recently, some detailed studies have been made of the physicochemical changes in the various stages while preparing tamra (Cu) bhasma by light microscopic, electron scan microscopic, X-ray diffraction and thermal gravimetric techniques using standard protocols29. Initially, copper sulfides and some new metallic complexes are synthesized but eventually it is free of copper. The particle size in the end product reaches colloidal levels. The study also found that the bhasma when given in higher doses to rats does not get absorbed in the gastrointestinal tract but gets excreted. A study on the neurotoxic effect and accumulation of methyl mercury and mercuric sulfide (HgS) in rats indicates that insoluble fo

rm of inorganic HgS

can be absorbed from the G-I tract and that its neurotoxic potency is about one thousand times less than that of soluble MeHg30. In another study, swarna (Au) bhasma was prepared as per the classical texts and was analyzed for its metal contents using atomic absorption spectrometry31. An infrared spectroscopy was performed that revealed it to be free of any organic compounds. Its acute oral administration showed no mortality nor did a chronic administration show any toxicity in experimental animals. Also, the bhasma was found to have antioxidant property.

 Nanosubstances (0.1-100 nm) can have special physical and chemical properties. These are comparable to the size range of biological structures and so are potential substance for manipulation, sensing and detection of biological systems. A single atom is 0.1 to 0.2 nm in size, a strand of DNA is 2 nm wide while a red blood cell is about 7,000 nm. Substances such as metal oxide nanoparticles, nanogold particles and carbon based nanomaterials (fullerenes, nanotubes, nanodiamonds), etc. are being viewed as nanomedicine, with a variety of biological applications, in the diagnosis and treatment of 
a wide variety of diseases. At these scales, many substances can develop toxicity too. Experiments with zinc oxide nanoparticles (nZnO) have shown selective toxicity to different bacterial systems and human 
T lymphocytes32. Gold and its compounds have been known for their therapeutic utility. A standardized colloidal gold preparation (Tyndall's purple, Au°, 
27 nm) has been found to be a far more effective anti-arthritic agent in rats than the sodium aurothiomalate used in the treatment of rheumatoid arthritis33. The administration route was subcutaneous; attempt was to examine if the classic swarna bhasma can also be similarly suitable. Swarna bhasma (42 iterations, 
900 C) was prepared brown red in colour following classic texts (Rasaratnasamuchchya and Sarangdhara-Samhita). An infrared spectrum showed no presence of organic compounds and transmission electron microscope (TEM) measurements revealed average particle size to be 57 nm with globular morphology. An atomic absorption spectroscopy indicated the bhasma to be free of any mercury but having 92% zerovalent gold (Au°) in the bhasma. These nanogold particles should be able to reach the affected site even if administered orally and provide a slow and sustained release of Au (I) ions33. By itself, this is a highly promising area for further studies on treatment of diseases.

 However, an altogether different form of a bhasma, obtained following a classical bhasma process has been used. The swarna bhasmaprocess is a temperature sensitive one  and one must settle it if the swarna bhasma so obtained - predominantly a colloidal metallic gold - is a drug intermediate only since the bhasma process in general is so designed as to produce an oxide, free of organic and metallic particles. The classic texts describe a method involving aqua regia etc. to produce pure and fine yellow coloured gold powder which is used as medicine, in place of gold foils but it does not involve incineration4,24. As an aside, note that colour of a colloid can differ depending on particle size, shape and mutual separation, and refractive index of the medium. Nanogold particles 2-30 nm in size in a colloidal suspension are bright red in colour and their colour changes to purple and blue as the size gets larger as a result of a phenomenon called surface plasmon resonance34. Nanodiamonds are being considered as a potential drug delivery agent that can carry drugs to certain parts of a damaged cell where larger carbon based nanoparticles cannot reach and interestingly the left-over nanodiamonds do not induce inflammation in cells. Their impact on humans and other biological systems is being studied. It has been demonstrated that 2-10 nm nanodiamonds are biocompatible with a variety of cells of different origin and are nontoxic35. Nanodiamonds can for example be produced in a detonation of TNT/RDX 
at 5 Gigapascals and 2,000°C. The nanodia

mond concept differs a

ltogether from that of a vajra bhasma and so a correspondence can not be made. The bhasma process does not create nanodiamonds as an end product since powdered diamond will be only oxidized away in the numerous incinerations. Nanomedicine is regenerative medicine, for the treatment or repair of tissues and organs, within the targeted cells. The classic bhasma could qualify to be in the new age nanomedicines realm but the correspondence should be done within propriety. Cheap surely but whether therapeutically suitable is another matter that requires detailed studies, particularly of the toxicities.

 

 The Indian medicines were subjected to critical examination using the standards applied to western medicine where permissible limits to the presence of a toxic heavy metal in a formulation are established1. The work is about metal-contents and not a study of metal toxicities among populations resulting from use of such medicines. Also, the metals chemical forms, which can impact bioavailability and toxicity could not be ascertained. This important aspect has not received the attention it deserves. As inorganic compounds and in prescribed dosages, they are less likely to accumulate in the body. With particle sizes in the micron to near nanoscale range, the absorptivity of the metal bhasmas is presumably better than an ordinary mineral taken in powdered form. Between them, these factors are contrapositive but can also strike a kind of a balance. If the preparations have been done as expounded in the texts, the toxicity aspect is constrained because the compounds have been traditionally in use. All of the bhasma metals are not toxic. The Ayurvedic Formulary of India as also the National Formulary of Unani Medicine list several formulations that contain malla (arsenic) as an active pharmaceutical ingredient. The upper limit to the per diem dosage is 10 mg, for an adult. The formularies do permit usage of As. In very small doses, it is stomachic, general and nervine tonic, alterative, respiratory and sexual stimulant as per the texts22. There are several metal compounds considered poisonous but are permitted to be used in an ISM formulation. There are numerous vaidyas and ISM drug manufacturers who have developed formulations from less controversial drug material, permitted to be used in ISM, and claim positive results. These need a multifaceted study, like any modern medicine today.

 

 The concerns in the study notwithstanding, use of inorganic chemical substances in medicine has been widespread in the West, well into the 20th century and these have been part of pharmacopoeias1. One can cite here substances such as compounds of mercury, copper sulfate, alum, magnesia, borax and green vitriol, etc. The West has used arsenic trioxide over the past 200 yrs as a part of medicine, including the treatment of cancer. The Food and Drug Administration in 2000 approved arsenic trioxide for the treatment of patients with acute promyelocytic leukemia that is resistant to ATRA. One can see a number of tonics in US, UK, etc. which contain a number of minerals including vanadium, manganese, chromium, selenium, etc.

Ref:
http://www.niscair.res.in/sciencecommunication/researchjournals/rejour/ijtk/Fulltextsearch/2010/July%202010/IJTK-Vol%209(3)-July%202010-pp%20562-575.htm

Dr.suresh Jakotia:
Try Surankanda with tankan bhasma lepa.

Dr.kamal:
http://ayushdhara.in/index.php/ayushdhara/article/view/237/198

Successful case study..today published in ayushdhara journal..

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